My favourite (or the most often used) shortcuts in Visual Studio 2015:
Editing:
Ctrl+X – cut the line (you don’t need to select the text in line, just put the cursor).
Ctrl+C – copy the line (see above).
Ctrl+V – paste the line (see above).
Ctrl+Shift+L – delete the line (see above).
Ctrl+Shift+V(multiplied) – show clipboard history.
Ctrl+, – search for classes, methods and so on.
Ctrl+F – find next.
Ctrl+Shift+F – find all.
Ctrl+-/Ctrl+Shift+- – go to previous/next place when you edited the code.
Alt+Down/Up – move code up or down.
Ctrl+K+D – format the code.
Ctrl+K+F – format the selected code.
Ctrl+] – go to closing “}” or opening “{” bracket (use when cursor is next to opening or closing bracket).
Ctrl+G – go to line number.
Ctrl+K+C – comment selected text.
Ctrl+K+U – uncomment selected text.
Ctrl+Shift+W – select current word.
Shift+Alt+. – select next occurence of selected word
Ctrl+S – save file.
Ctrl+Shift+S – save all files.
Ctrl+R,R – rename.
Ctrl+Enter – put new line above cursor.
Shift+Enter – put new line below cursor.
Ctrl+Alt+Click+Click+… – allow editing in multiple places at the same time
Snippets:
propfull+tab+tab – insert snippet for property with backing field.
propdp+tab+tab – insert snippet for dependency property.
Debugging:
F10 – step out.
F11 – step in.
F5 – run.
F9 – add/remove breakpoint.
Windows:
Alt+F7 – move along windows.
Ctrl+Tab – move along active files.
Ctrl+Shift+Alt+Up – members list.
Alt+F12 – peek definition; when your cursor is on a method call, new window with body of this method is displayed and you can edit it here.
Ctrl+Alt+I – Immediate window.
Ctlr+Alt+O – Output window.
Ctrl+Alt+P – attach to process.
Ctrl+Alt+A – commands window.
F4 – properties window.
Ctrl+Alt+L – Solution explorer window.
Shift+F10 – context menu.
Others:
Ctrl+F4 – close document window.
Ctrl+T+R – shows recently opened files
Ctrl+K,K – add/remove bookmark.
Ctrl+K,N – go to next bookmark.
Ctrl+K,P – go to previous bookmark.
F6 – build solution.
F12 – go to (method) definition.
Ctrl+F12 – go to declaration.
Ctrl+Shift+Backspace – go to last edited code
Ctrl+- – go to last cursor position
Ctrl +R,T – debug unit test (works when your cursor is in unit test method body)
Of course there are much more shortcuts defined in Visual Studio: http://visualstudioshortcuts.com/2015/